Clinically, this is manifested by headache, dizziness, insomnia, weakness, apathy, and lethargy. There may be a kind of aczone pills, meningeal symptoms, delirium, drowsiness, blurred vision, diplopia, drooling, paralysis of the eye muscles, mask-like face, muscle twitching. Cerebral emboli are observed in 30% of patients with IE. Sterile emboli cause heart attack and hemorrhage, while infected emboli cause meningitis, encephalitis, and brain abscess. Signs of brain damage can be either the first symptoms of the disease or later ones, appearing after monthsand years.
Signs of central nervous system involvement in patients with fever or a heart murmur should suggest the possibility of aczone gel. Damage to the spleen in IE consists of its hyperplasia and multiple infarctions due to embolism and thrombosis. Splenomegaly currently occurs in 30-40% of patients. In the acute course of IE, the spleen is not clearly palpable, it has a soft consistency and is not sharply enlarged. In the chronic course, the spleen is moderately enlarged at the beginning; palpation reveals a dense, slightly painful edge.
Over time, the spleen enlarges more significantly, often to the point of pronounced splenomegaly, and becomes dense and painless. With early and successful treatment with antibiotics, the spleen shrinks and is no longer palpable. The presence of an enlarged spleen indicates the ineffectiveness of treatment. Splenic infarctions are accompanied by acute sudden pain in the left hypochondrium with irradiation to the left shoulder and left atrial region. At the same time, vomiting, chills, fever, and leukocytosis are noted.
On palpation, tension in the abdominal wall and pain in the left hypochondrium are noted. There is limited mobility of the lung on the left. Sometimes you can hear a peritoneal friction sound in the area of the spleen. Reactive pleurisy may develop. Within 2-3 days, the described symptoms usually subside and then gradually disappear. IE can lead to the formation of splenic abscesses. Such an infected spleen may cause persistent fever and bacteremia. Sometimes the first manifestation of IE is splenic rupture.
In such cases, detection of free blood or pus in the abdominal cavity serves as an indication for immediate surgical intervention. Liver damage in IE is associated with the development of heart failure or infectious-toxic hepatitis. Liver enlargement is observed in approximately 90% of patients.
Already in the early stage of the disease, simultaneously with an enlargement of the spleen, a dense, painful edge of the liver is determined, even in the absence of signs of congestive right ventricular heart failure. Typically, this hepatosplenomegaly occurs without severe jaundice and necrosis of liver cells, but with signs of severe hypergammaglobulinemia. In patients with IE, icterus of the sclera and skin is quite common. Serum bilirubin is increased in 30% of patients due mainly to buy aczone online, but sometimes bound bilirubin.
Only a small proportion of patients may develop severe jaundice with liver failure. Other complications may include liver abscesses and thromboembolism. Lesions of the gastrointestinal tract in IE are associated with the development of embolism and congestion.
Patients often complain of lack of appetite, pain in the abdomen, and right hypochondrium. Nausea and vomiting are usually late symptoms, depending on heart failure, uremia or brain disorders. Sudden and sharp abdominal pain is most often caused by infarctions of the spleen, kidneys, and intestines. With intestinal infarctions, bloody diarrhea is observed. Diarrhea can also be caused by uremia. Lung damage is manifested by heart attacks, pneumonia and edema in left ventricular heart failure.